Sadia Rehman, Santosh Kumar, Abdul Manan Junejo, Fatima Mehboob, Hasan Ali, Noorun Nisa Memon.
Impact of Oxidative Stress on Hypertension in patients on Maintenance Haemodialysis.
Ann Jinnah Sindh Med Uni Jan ;5(1):15-20.

Objective: To assess the association of oxidative stress with hypertension and its correlation with the duration of haemodialysis Methodology: It was a case control study conducted in a public sector tertiary care hospital in 2017. The study participants were recruited from the nephrology ward while the healthy controls were taken from participant neighborhood through frequency matching. Non probability consecutive sampling technique was employed. Cases included were suffering from chronic renal failure and were receiving maintenance haemodialysis. Exclusion criteria was patients suffering from any other chronic illness other than chronic renal failure (pulmonary disease and hepatic insufficiency). Detailed analysis was done with application of ANOVA, Pearson correlation and independent sample t test. P value less than 0.05 was taken as significant. Results: Highly significant difference was observed in mean serum malondialdehyde, mean plasma superoxide dismutase, mean systolic blood presure, and mean BMI among the cases and controls (p value < 0.001). Positive linear correlation was found between blood presure and serum malondialdehyde i.e. (r = 0.4) while on the other hand strong negative correlation was found between blood presure and plasma superoxide dismutase i.e. (r = -0.73). Conclusion: Oxidative stress worsens with progression of haemodialysis and leads to development of hypertension.

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