Inayat Ullah, Mahrukh Naseem, Muhammad Iqbal Yasinzai, Asmat Ullah Kakar, Zahoor Ahmed, Asma Abdul Ghani, Zafar Ullah, Azmat Ullah.
Effect of insulin verses metformin on hyperglycemia and dyslipidemia in type-ii diabetic patients.
J Med Sci Jan ;27(4):302-6.

Objective: To compare the anti-hyperglycemic and anti-dyslipidemia effects of insulin verses metformin in diabetic human subjects.Material and Methods: Total of 240 blood samples were collected (120 from male and female) for all the three groups i.e. Group-I serve as non-diabetic individuals, Group-II included diabetic patients treated with insulin and Group-III included diabetic patients treated with metformin. The study period was from January 2018 to September 2018. Fasting-serum-glucose, lipid profile, triglyceride, AST and ALT analysis were done with serum samples. Body mass index was also measured for each subject.Results: A significant weight gain was recorded in metformin treated group than insulin treated group. Insulin showed more significant anti-hyperglycemic effects than metformin treated group. Insulin therapy showed more significant reduction for total-cholesterol and very low density-lipoprotein both in male and female groups. For low-density-lipoprotein a significant reduction and for high-density-lipoprotein a significant increase was found only in male insulin treated group.Insulin also showed significant increase for alanine aminotransferase, aspartate aminotransferase only in male group. Conclusion: Insulin showed stronger anti-hyperglycemic, anti-hypercholesterolemia activities than metformin. Insulin showed more significant improvement in lipid profile.

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