Asad Ali Kerawala, Nighat Bakhtiar, Syeda Sakina Abidi, Saima Awan.
Association of gallstone and helicobacter pylori.
J Med Sci May ;27(4):269-72.

Objective: To determine the association of helicobacter pylori as a risk factor for cholelithiasis. Material and Methods: This case control study was done at Dow University Hospital, Karachi ,Pakistan,from October 2017 to April 2018.Total 90 patients, 45 in each group complaining of upper abdominal pain, with gallstones diagnosed on ultrasound other 45 patients coming to hospital with any pathology other than gallstones were selected in this study. Serum H.pylori antibodies test were done on all the patients. Those with the presence of gallstone were offered laparoscopic cholecystectomy.Results: The average age of the patients was 40.83±10.85 years. Risk of serum H.pylori antibodies was less likely in case than control [OR=0.475; 95%CI: 0.16 to 1.42] but there was no significant association between H. pylori and gallstones (p=0.178).Conclusion: There were no significant association between H.pylori and gallstones. There is a need of more studies in order to determine the role of Helicobacter in hepatobiliary diseases and also for the development of specific tests to identify these bacteria.

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