Amina Rasul, Nadia Latif, Sajid Ali, Mehvish Ashfaq, Sadia Mubarak, Irum Rehman.
Taurine supplementation normalizes skeletal muscle functions in type 2 diabetes rats.
Pak Armed Forces Med J Jan ;70(1):224-29.

Objective: To study effect of supplementation of taurine on force frequency relationship and fatigue of rodent skeletal muscles in type 2 diabetes mellitus. Study Design: Laboratory-based experimental study. Place and Duration of Study: Department of Physiology at Army Medical College Rawalpindi, from Apr 2013 to Jun 2013. Methodology: Ninety Sprague-Dawley rats were divided randomly in to 3 groups; control (group-1), beta-alanine (group-2), and taurine group (group-3). All rats were fed with taurine free-high fat diet and administered streptozocin to induce type 2 diabetes mellitus. In addition, group-1 was supplemented with 0.02% (w/v) taurine, group-2 with 3% (w/v) beta-alanine, and group-3 with 3% (w/v) taurine in their respective drinking water. At 21st day, plasma glucose and insulin resistance were measured to affirm type-II diabetes mellitus in all groups. At 28th day, contractile functions of extensor digitorum longus muscles at high frequencies were evaluated using i Worx data acquisition unit (AHK/214). Results: The decline in maximum fused tetanic tension, maximum fused tetanic tension after fatigue protocol, and recovery from fatigue was significantly ameliorated in taurine supplemented diabetic rats. Conclusion: Taurine supplementation significantly improved the contractile functions of diabetic rodent skeletal muscle at high frequency stimulation.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com