Aamir Hussain, Muhammad Ammar Rashid, Waqar Mustafa, Sehrish Javed, Zeeshan Malik, Muhammad Irfan Tahir Khan.
Frequency of Achieving Normal Level of High Density Lipoprotein by Using Statins in patients with Acute ST Elevation Myocardial Infarction.
J Cardiovascular Dis Jan ;15(3):73-6.

BACKGROUND AND OBJECTIVE:The concentration and composition of the lipids is modified during the acute episodes of myocardial ischemia. There are many risk factors of ischemic heart disease out of which hyperlipidemia has significance regarding its evaluation and management. Statin effects the levels of low density lipoprotein (LDL) as well as high density lipoproteins (HDL). If the levels of HDL are normal the process of atherosclerosis can be prevented. The purpose of this study was to assess the frequency of achieving normal level of high density lipoprotein by using statins in patients with acute ST elevation myocardial infarction (STEMI). MATERIAL AND METHODS:This was a descriptive case series, conducted at Cardiology department of Punjab Institute of Cardiology, Lahore over a duration of six months from 04-08-2017 to 06-02-2018. 145 patients fulfilling the selection criteria were registered in the study. All patients received 40mg of simvastatin in addition to routine medication. Follow-up of patients was done after 8 weeks and HDL level was assessed. A level of >45mg/dl was considered normal HDL level. RESULTS:The mean age of patients was 57.41+-13.05years. There were 92 (64.8%) males while 51 (35.2%) were females. The mean BMI of patients was 25.04+-5.51kg/m2. Thrombolysis was done in 98 (67.6%) patients while 47 (32.4%) patients were not given thrombolysis due to late presentation. The mean HDL after 8 weeks of treatment was 53.89+-8.96mg/dl. There were 130 (89.7%) patients in which normal HDL was achieved with stain treatment while in 15 (10.4%) patients normal HDL was not achieved. CONCLUSION:The dyslipidemia can be treated with the use of stains which can help to improve the levels of HDL in short duration of time.

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