Abdulhalim Salim Serafi.
Correlation of Serum Homocysteine and Low Density Lipoprotein Cholesterol in Hypertensive Female patients.
J Cardiovascular Dis Jan ;15(3):59-62.

BACKGROUND AND OBJECTIVE: Previous studies suggest that there is a correlation in hyperhomocysteinemia and dyslipidemia which may lead to hypertension and atherosclerosis. However, there is limited data available regarding association of rising levels of homocysteine (Hcy) and lipid abnormalities. Two of the important factors considered to be involved in the pathogenesis of hypertension are homocysteine (Hcy) and (LDL-C) low density lipoprotein cholesterol. However, still there is controversy about the precise role of LDL-C and Hcy in subjects with hypertension. This study was planned to see correlation of homocysteine levels and low density lipoprotein levels in hypertensive females. MATERIAL AND METHODS: This was case-control observational study, conducted at Physiology Department, Alnoor Specialist Hospital in Makkah, Saudi Arabia over a period of two years from January 2017- January 2019. A total number of 42 female patients were enrolled. The subjects were divided into two groups. One group consisted of 22 hypertensive females (cases) and the other group (control) had 20 normotensive females. The two groups were matched for variables like age and gender. The blood sample of all the patients were collected and sent to pathology lab for determination of Hcy and LDL-C level. The data was analyzed to see the correlation between the plasma Hcy and LDL-C level. RESULTS:The plot of Hcy against LDL-C showed no significant linear correlation for normal healthy controls (R2: 0.0555; p-value >0.291) but highly significant linear correlation for subjects with hypertension (R2: 0.4366; p-value >0.0015). In hypertensive females group Hcy and LDL-C were having appreciable correlation as compared to control group. CONCLUSION: Increased Hcy level was positively correlated with LDL-C in hypertensive females.

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