Imran Waheed, Zeeshan Hassan, Sajjad Ahmad, Syed Moazzam Ali Naqvi, Ali Javaid Chughtai, Ahmed Noeman.
efficacy of allicin in patients with hyperlipidaemias.
J Cardiovascular Dis Jan ;16(1):24-7.

BACKGROUND:Hypercholesterolemia and other Hyperlipidemias are the most commonly encountered disorders in patients suffering from Obesity, Diabetes Mellitus, Hypertension and Ischemic Heart Disease besides being a routine finding in individuals without any risk factors mentioned above. Whether it is a primary disorder of lipid metabolism, an inherited familial hyperlipidemia or due to any secondary cause, these predispose to coronary artery disease, cerebrovascular accidents, peripheral vascular disease and their fatal complications. Statins or HMG Co A reductase inhibitors are the drugs which have been used for the treatment of hyperlipidemias. Their sided effects have limited their use in many settings in spite of being very useful. Liver damage, myalgias, renal impairment and above all recent onset of diabetes mellitus has been reported with the use of these drugs. Much has been explained about the adverse effects of these drugs but no alternative medicine has been studied in trials available till now. There is deficiency of literature regarding availability of alternative of statins or HMG Co A reductase inhibitors for treatment of hyperlipidemias. OBJECTIVE: To study the efficacy of Allicin in patients with Hyperlipidemias. MATERIAL AND METHODS: This experimental observational study done at Preventive Cardiology Clinic and Cardio metabolic OPD Departments of Cardiology, Government Khawaja Muhammad Safdar Medical College, Sialkot from 1st November 2019 to 30th November 2019. A total number of 100 patients with Hyperlipidemias were enrolled in the study. Informed consent was taken from all the patients after explaining the nature of drug used and dosage schedule. A fasting Lipid Profile was done in all cases under study and the results were recorded on a pre designed proforma. The guidelines of National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) were used for classification of Lipid Abnormalities detected on laboratory results. All patients were given Enteric Coated Tablets of Garlic containing active ingredient Allicin orally in a dose of 300 mg thrice daily for one month.. Patients remained on weekly Cardiology Metabolic clinic outpatient department follow up during the study period. At the end of one month a Fasting Lipid Profile was again repeated in all cases under investigation and the laboratory reports were recorded for final evaluation. The data collected was analyzed statistically on SPSS for windows version 21. RESULTS: . Allicin therapy had promising results on different fractions of Lipid Profile. There was overall reduction in total cholesterol from 239.5 to 163.9 mg/dl , LDL cholesterol reduction was observed from a mean value of 157.67 to 123.38 mg/dl while VLDL values did not show any improvement with Allicin therapy however HDL values improved from 35.65 to 39.5 mg/ dl. Triglycerides reduced from 273 to 134 mg/dl at the end of study period. CONCLUSION: We conclude here that as an alternative to Statin therapy for those patients who suffer from side effects of Statins Allicin therapy may be a good option. Key words: Efficacy of Allicin, hyperlipidemias, coronary artery disease.

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