Kumayl Abbas Meghji, Rizwan Ali Talpur, Arsalan Ahmed Uqaili, Yar Muhammad Nizammani, Navaid Kazi, Ghulam Shah Nizammani.
Resveratrol attenuates oxidative stress in chemotherapy induced acute kidney injury: an experimental rat model.
Khyber Med Uni Med J Jan ;11(2):85-9.

OBJECTIVE: To investigate the anti-oxidative and anti-nephrotoxic effects of resveratrol in cisplatin induced nephrotoxic albino Wistar rats. METHODS: This quasi-experimental study was performed at Isra University, Hyderabad, Pakistan. Thirty male albino Wistar rats were divided into three groups: group-A (control), group-B (cisplatin) and group-C (cisplatin+resveratrol). Biochemical [serum urea, creatinine and glutathione peroxidase (GPX)] and renal histomorphology was performed in all groups after 21 days of treatment. RESULTS: Difference in mean pre- and post-experimental body weight was observed in all three groups. Mean body weight decreased from 241.7+8.5 gm to 196.50+9.34 gm and from 237+7.4 gm to 207.2+6.56 gm in group-B and group-C respectively. In group-A; mean serum urea was 22.7+2.66 mg/dl, serum creatinine was 0.45+0.05 mg/dl and serum GPX was 1.44+0.13 ng/ml. In group-B; mean serum urea level was 51+3.65 mg/dl, mean serum creatinine was 0.78+0.05 mg/dl and serum GPX was 0.85+0.11 ng/ml. In group-C, mean serum urea level was 32.8+1.45 mg/dl, serum creatinine level was 0.41+0.09 mg/dl and serum GPX was 1.53+0.08 ng/ml. In group-A, renal structure was intact, marked changes were observed in renal histology of group-B while group-C displayed less glomerular damage. CONCLUSION: Resveratrol therapy is a potent anti-nephrotoxic regime showing promising results in chemotherapy induced nephrotoxicity and oxidative stress.

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