Muhammad Ibrahim, Syed Maisam Ali, Mohammad Imran Shah, Muhammad Abkar Khan.
Microorganisms profile and anti-microbial sensitivity in chronic suppurative otitis media.
Khyber Med Uni Med J Jan ;11(4):248-53.

OBJECTIVE: To determine the frequency of common microorganisms involved in chronic suppurative otitis media (CSOM) and their antibiotic sensitivity. METHODS: This cross sectional study of 776 patients suffering with CSOM was conducted at Otolaryngology Department, Ayub Teaching Hospital, Abbottabad from 5th May 2017 to 5th November 2018. Patients fulfilling the inclusion criteria were enrolled for otoscopic examination. Sterile cotton swabs were used to collect pus samples and were sent to microbiological analysis and antibiotics sensitivity. RESULTS: The age ranges of the patients were from 13-73 years, with a mean age of 28.98+-13.40 years. The incidence of CSOM was highest in 21-30 years age group (294~37.9%). In a total 776 CSOM patients, only 501 (64.56%) of the samples showed microbial growth. In aerobic isolates, the most common bacterium was Pseudomonas aeruginosa (30.7%) followed by Staphylococcus aureus (11.1%) including 6.7% MRSA. Anaerobes were isolated in 1.2% of the samples in which bacteriodes were being the most common. Samples (1.8%) showed fungal growth and yielded only Candida spp while 0.5% samples were positive for acid fact bacilli. In antimicrobial sensitivity investigation Pseudomonas aeruginosa showed highest sensitivity to piperacillin/tazobactum (84%), to levofloxacin (25.21%), to ciprofloxacin (20.59%). The highest sensitivity of S. aureus was investigated for piperacillin/tazobactum and ceftazidime with 91.18%, and showed no sensitivity to ciprofloxacin and levofloxacin. CONCLUSION: Pseudomonas aeruginosa and Staphylococcus aureus were the most common bacteria. Both show increasingly high resistance to quinolones and amino glycosides, but both isolates are sensitive to piperacillin/tazobactum, imipenam, cefoperazone/salbactum and ceftazidime.

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