Rizwan Ali Talpur, Kumayl Abbas Meghji, Arsalan Ahmed Uqaili, Navaid Kazi, Ghulam Shah Nizammani, Sumayya Qazi.
Anti-hyperglycemic and anti-oxidative effects of L-carnitine administration in alloxan induced diabetic albino wistar rats.
Khyber Med Uni Med J Jan ;11(4):204-8.

OBJECTIVE: To evaluate anti-hyperglycemic and anti-oxidative effects of L-carnitine in alloxan induced diabetic albino wistar rats. METHODS: This quasi-experimental study was conducted at Isra University, Hyderabad from June 2017 to August 2017. Thirty-six albino wistar male rats were equally divided into 3 groups (n=12/group); group A (control), group B (alloxan 150mg/kg intraperitoneally) and group C (alloxan 150mg/kg intraperitoneally + L-carnitine 500mg/kg orally for 21 days). Diabetes was induced in group B and C by single intraperitoneal dose of alloxan 150mg/kg body weight and rats having blood glucose >200mg/dl were labeled as diabetic rats and included in study. Biochemical (blood glucose, serum insulin and glutathione peroxidase) and histopathological analysis of pancreas was performed in all three experimental groups. RESULTS: Post-experimental body weight in groups A, B and C were noted as 249.58 +- 6.63, 199.08 +- 12.18, 210.58 +- 5.14 grams respectively. The fasting blood glucose in groups A, B and C were noted as 104.58 +- 7.05, 221.25 +- 8.22, 110.17 +- 12.85 mg/dl respectively (P<0.001). Serum insulin in groups A, B and C was noted as 1.45 +- 0.083, 0.31 +- 0.16, 1.74 +- 0.23 ?g/ml respectively (P<0.001). Glutathione peroxidase levels in groups A, B and C were noted as 1.45 +- 0.17, 0.93 +- 0.11, 1.74 +- 0.17 ?g/ml respectively (P<0.001). Histopathology of pancreas showed reduction in size (mean islet diameter 157 +- 1.5 +- m) and number of islets of Langerhans in diabetic rats, while L-carnitine treated rats have shown compensatory increase in size of islets of Langerhans (mean islet diameter 210 +- 6.3 +- m). CONCLUSION: L-carnitine therapy is a potent anti-hyperglycemic and anti-oxidative regimen capable of reducing blood glucose and increasing plasma anti-oxidant levels.

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