Rubina Shafi, Muhammad Nadim Akbar Khan, Ammar-ul Hassan, Muhaaimin Nawaz, Fakhra Noureen, Shazia Qayyum.
The Association of Total Antioxidant Capacity with Metabolic Syndrome.
J Islamic Int Med Coll Jan ;15(1):14-8.

Objective: To determine the association between Total antioxidant capacity (TAC) with metabolic syndrome Study Design: A cross sectional study design. Place and Duration of Study: The study was conducted at department of Chemical Pathology, Islamic International Medical College Pakistan Railways Hospital, Rawalpindi. One year (2nd Sep 2018 to 2nd September 2019). Materials and Methods: A total of 88 subjects, 44 with metabolic syndrome and 44 controls were recruited through non probability convenient sampling. Group I comprised of 44 metabolic syndrome individuals from both genders. Patients having FPG >= 100mg/dl were investigated for TG and HDL-C and their waist circumference and BP was measured. According to AHA/NHLBI guidelines, the individuals were labeled with MS on fulfilling three or more than three criteria i.e Fasting Plasma Glucose > 100mg/dl, Serum Triglycerides > 150mg/dl, HDL-C <= 40mg/dl in men and <= 50 in women, Blood Pressure > 130/85 and waist circumference > 40" 8 in men or > 35`` in women. Group 2 comprised of 44 healthy individuals. In addition to the above mentioned lab tests, Total Antioxidant capacity (TAC) was measured for both the groups. Statistical Package for Social Sciences (SPSS) version 23.0 was used for entering and analyzing all data. Descriptive statistics were described for nominal data; mean and standard deviation were described for quantitative variables which included serum TAC, FBG, serum HDL-C, serum triglycerides, waist circumference and BP measurement. Results: The mean age of metabolic disease group was 48.14 + 10.48 years, and that of control group was 23.04 + 5.82 years. TAC recorded levels were found to be considerably higher in the control group (18.13 +- 12.90 mmol/L) as compared to the Metabolic Syndrome group (4.56 +-.7.43). Serum HDL-C (37.09 + 6.37 mg/dl) vs (43.09 + 46.15 mg/dl) levels were lower in MS individuals. Whereas, Triglycerides (240.03 +- 93.19) vs (107.41 +- 56.50), FPG (139.43 +-57.56) vs (69.66 +- 30.46), BP (133.86 mm Hg + 13.59) vs (120.00 + 0.00) were found to be higher in MS patients as compared to control group. Conclusion: TAC gets depleted in MS individuals more as compared to healthy individuals. Estimation of TAC at an early stage can be useful for early detection of Metabolic Syndrome and further to prevent its complications such as DM, CVD and other metabolic disorders.

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