Faisal Rafiq, Muhammad Akhlaq, Waseem Ahmad, Barik Ali M Mubarik, Abdur Rehman, Khalid Mahmood Javid.
Single Intravenous Dose of Dexamethasone for the Prevention of PostTonsillectomy, Nausea and Vomiting: Does it work?.
Med Forum Jan ;31(1):63-6.

Objective: To compare the post-tonsillectomy nausea and vomiting with and without a single intra-operative intravenous dose of dexamethasone 0.5mg/kg. Study Design: Randomized controlled trial Place and Duration of Study: This study was conducted at the Department of ENT, Sir Ganga Ram Hospital Lahore from August 2018 to August 2019. Materials and Methods: One hundred and forty patients were equally divided into two groups. Group I was treated with dexamethasone 0.5mg/kg and Group II was treated without dexamethasone. Complete laboratory examination was done. Tonsillectomy was performed by sharp dissection snare technique in all the patients by the same surgeon. Post-operatively 8-hourly Amoxicillin/clavulanic acid 15mg/kg orally, paracetamol 15 mg/kg and povidone iodine mouth wash were given to all the patients. Results: The mean age in Group I was 12.37+-5.84 and in Group II it was 10.82+-4.37 year. There were 34 (48.6%) males in group I and 36 (51.4%) males in group II, while females were 36 (51.4%) in group I and 34 (48.6%) in group II. Postoperative nausea and vomiting was observed in 5 patients (7.1%) of group I and 19 patients (27.1%) of group II (p=0.002). Mean duration of disease was 3.87+-1.21 and 2.96+-0.98 year in group I and II, respectively (Table-4). Mean BMI in group I was 17.96+-2.68 and in group II 17.47+-0.98 (kg/m2). Conclusion: Single intravenous dose of dexamethasone 0.5mg/kg intra-operatively is safe and effective for the prevention of post-operative complications such as nausea and vomiting in patients undergoing tonsillectomy.

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