Safeena Sidiq, Naseem Saud, Talha Laique, Kashif Butt, Ayesha Ahmad, Qaiser Jabeen, Maryam Rashid.
Hepatoprotective Effect by Methanolic Extract of Dinothrombiumtacnitoriumin Albino rats.
Pak J Med Health Sci Jan ;13(4):725-7.

Products of animal origin in traditional medicines are accountable for their healing importance. objective: the goal was to appraise hepatoprotective effect by methanolic extract of Dinothrombium tacnitorium in Albino rats. Study design: It was a randomised control study. Methodology: Aqueous methanolic extract (70% v/v) of Dinothrombium tacnitorium (Dt.Cr) was prepared followed by succeeding evaporation using rotary evaporator. Liver toxicity was done by introduction of CCl 4 (2 ml/kg, p.o) in paraffin oil on 7th day of experiment. Administration of methanolic extract of Dinothrombium tacnitorium (300mg/kg body weight/day) orally protected the CCl4 caused elevation of liver enzymes that include Aspartate aminotransferase, Alanine aminotransferase, Alkaline Phosphatase and total bilirubin. The hepatic enzymes level elevation in the CCl4 alone treated animals. Administration of methanolic extract to CCl4 challenge protected against the hepatic toxic agent. Conclusion: The findings thus suggested that the methanolic extract of Dinothrombium tacnitorium (Dt.Cr) can be used as hepatoprotective agent against CCl4 induced hepatotoxicity in albino rats.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com