Amtul Huda, Sadia Zia, Memon Muhammad Khan, Hooria Aamir, Zulfiqar Alavicenna Medical College Lahore, Afsheen Akba, Bandar Mohammad M Alqahtani.
Correlation between hyperuricemia and rapidly decline kidney functions.
Pak J Med Health Sci Jan ;13(4):785-7.

Background: The patients of chronic kidney disease (CKD) are recurrently come across with Hyperuricemia . We weathered the assumption that influence of uric acid on glomerular filtration rate (GFR) and is linked with decline in kidney function in aged Pakistani patients. Methods: About 200 aged subjects’ ranges 60 -70 years were registered for their routine follow up medical health check. Estimated GFR (eGFR) was calculated by means of the amendment of Diet in kidney Disease Study equation. eGFR < 60 ml /min/1.73m2 was used to examine the occurrence and frequency of (CKD ). The kidney function was significantly decline defined as reduction in eGFR in ≥ 2.9 ml/min/1.73m2 per yearly. Results: The pervasiveness of CKD was 19 .0% in the aged patients. The calculated Mean serum uric acid level was 7.5 mg/dl in males and 6.0 mg/dl in females, and eGFR was 70.5 ml/min/1.73m2. The levels of Uric acid were linked autonomously and pessimistically with eGFR after correction for predictable features of decline in kidney function. Out of two hundred fifty eight subjects 29% have observed significantly reduction in kidney function. The eGFR and uric acid levels linked each other as uric acid raised 1mg/dl, where as eGFR reduction raised by 1.207 Conclusion: The association of uric acid levels and eGFR leads to turn down the kidney function in aged Pakistani individuals. In future the hypo -uricemic treatment might slow down the succession of kidney function needs additional researches.

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