Masood Nizam Tabassum, Abdul Wahab Gureja, Shafaq Tabassum, Muhammad Usman Sheikh, Sana Noor, Nasir Ikram.
Clinical trial of linezolid in treatment of multi drug resistant tuberculosis at public sector hospital, Lahore.
Pak J Med Health Sci Jan ;13(4):796-9.

Background: The new drug for the treatment of multi drug resistant tuberculosis is Linezolid .A few numbers of trials has been conducted globally. Aim: To determine the clinical effect of Linezolid for management of multi drug resistant tuberculosis patients at Public sector Hospital Lahore. Methods: Randomized control trial was conducted in outpatient Department of Public sector Hospital Lahore from 1st January 2017 to 30 th June 2017 with informed consent from patients of multi drug resistant Tuberculosis of age more than 18 years. The population of whole Punjab was included in this study. Two groups were included. Linezolid group was prescribed Linezolid and Non -Linezolid group without Linezolid in addition to second line of ATT. Each group included 90 patients. The data was analyzed by SPSS version 22. Results: The mean age of cases in Linezolid group was 32.33± 12.19 years and in non Linezolid group was 31.87 ± 12.52 years. The median age in both study groups was same i. e. z = -7.16 . In linezolid group 51(56.67%) male and 39(43.33%) female and i n non -linezolid group 52(57.78%) male and 38(42.22%) were female cases. The gender distribution in both groups was same, In linezolid group 54(60%) cases were cured, 17(18.9%) cases were not cured and 19(21.1%) cases died while in non-linezolid group 30(33.33%) cases cured, 33(36.7%) cases were not cured and 27(30%) cases died. The cure rate was high in linezolid group with low mortality rate . Conclusion: In randomized control trial with Linezolid, 90% patients of multi drug resistant Tuberculosis were diagnosed with pulmonary Tuberculosis . Treatment with Linezolid drug proved to be effective in 60% cases with no side effect .

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