Zujaja Zaheer, Wardah Siddique, Nazia Rashid, Neelofar Yousaf Warraich, Ayela Eman Zia, Amna Asghar, Ajaz Fatima.
Evaluation of hepatoprotective effect of zinc sulfate against isoniazid and rifampicin in albino rats.
Pak J Med Health Sci Jan ;13(4):803-8.

Background: Liver diseases are becoming significant health problem which can lead to liver failure. Currently available therapies for liver failure , are ineffective with the exception of organ transplantation. Aim: Development of alternative methods for treatment of liver pathology are in great demand so regenerative medicines offer newer approaches for prevention of liver disorders. Methods: Zinc sulfate is promising agent available to treat patient with hepatotoxicity. It has antioxidant properties. Hepatoprotective effect of Zinc Sulfate was evaluated against Isoniazid 50mg/kg/day and Rifampicin 100 mg/kg/day combination induced hepatotoxicity , in this study . Results: 21 rats were divided into 3 groups (containing 7 rats in each group). Liver injury was induced by Isoniazid and Rifampicin combination in G2, 3. Hepatoprotective effect of Zinc sulfate 7mg /kg/day was evaluated in G3 by serum ALT, ALK PO4, AST, total bilirubin, total protein, albumin, globulin, A/G ratio (LFTs) analysis. There was significant elevation of serum ALT, ALK PO4, AST, total bilirubin indicating development of hepatotoxicity while total protein, albumin, globulin, A/G ratio were not significantly altered. The levels of ALK PO4, AST and Total bilirubin were significantly reduced (p value < 0.0001 ) in group G3 treated with Zinc Sulfate. Conclusion: This study proved hepatoprotection of Zinc sulfate by improvement in deranged LFTs.

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