Saba Amjad, Muhammad Suhail, Saba Saleem, Asma Zulfiqar, Saqib Mansoor, Uzma Ali.
Prophylactic role of curcumin against presence of mononuclear cell infiltrates in the interstitium of kidneys caused by aspirin in adult female albino rats.
Pak J Med Health Sci Jan ;13(4):914-7.

Background: The most frequently used non-steroidal anti-inflammatory drug worldwide to treat pain, inflammation and fever is Aspirin. Curcumin frequently referred to as “Haldi” is a chemical constituent of turmeric powder that is utilized in Ayurvedic medicine. Aim : To evaluate the nephro protective effects of curcumin against the presence of mononuclear cell infiltrates caused by aspirin with in the interstitium of kidneys in adult female albino rats. Study design: Experimental study. Methods: 15 rats were distributed in each of the 4 groups and study was conducted for 30 days. Aspirin (200 mg/kg bodyweight) was given to rats by orogastric intubation to induce nephrotoxicity in positive control group B and experimental groups C & D. Moreover, the rats of experimental groups C & D in addition to aspirin received 15 mg/kg & 30 mg/kg body weight of curcumin by oro gastric intubation. Results: On histopathological examination, the mononuclear cell infiltrates were not observed in control group A. However, the infiltrates were seen in all rats of positive control group B and 6 (40.0%) &4 (26.7%) rats in experimental groups C &D respectively . This difference was found significant with p-value 0.002. Conclusion: The present study has depicted that curcumin reduces the inflammation by decreasing the mononuclear cell infiltrates in the interstitium of kidney and the outcomes are dose dependent.

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