Zubda Anwar, Azka Anwar, Sumera Nighat, Muhammad Saqib, Sadia Anwar, Shaista Habib Alvi.
Metformin versus insulin treatment in gestational diabetes mellitus: their effects on neonates and women in 24 months’ follow-up.
Pak J Med Health Sci Jan ;13(4):1348-51.

Aim : To compare the metformin versus insulin treatment in gestational diabetes mellitus (GDM) in pregnant women and their effect on neonates and treatment effect on women up to 24th month post-partum follow-up. Methods: This was a randomized controlled study conducted study done in Private Hospital . The study conducted from 10th June 2016 to 10th June 2019. The study inclusion criteria was age above 18 years and the singleton pregnancy women who presented with GDM. We assigned 44 individuals to metformin treatment (group A) and another 44 individuals to insulin treatment (group B) by randomized method. The primary study outcomes were birth weight, pre-term birth, mother's and baby's weight at follow-up period. Results: The average gestational age in group A was 39.13±1.02 weeks and 38.52±1.69 weeks in group B (p - value=0.003). Preterm births were less in group A 10(22.7%) than group B 14(31.8%), the birth weight was 3.1±0.29 kg versus 3.6±0.29 kg (p -value <0.001), group A versus group B, respectively. Babies weight was 9.55±0.33 kg, 14.03±0.82 kg in group A, versus 9.36±0.21 kg, 13.16±0.21 kg at 12, and 24 months in group B. The women BMI was 26.16±0.33 kg/m 2 and 23.82±5.62 in group A and B at 12 months follow-up . Conclusion: We concluded that metformin exposed neonates had low birth weight and at follow-up period weight gain was more in these neonates. Those women treated with insulin therapy had a high incidence of pre-term births. Women taking metformin gain more weight after child birth.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com