Mufakhara Fatimah, Mahwash Malik, Sidra Mushtaq, Javeria Sarfraz, Zobia Mushtaq, Sadia Chiragh.
Dose Dependent Effect of Glycyrrhizin on Glycaemic Control of Type 2 Diabetic Rats.
Khyber Med Uni Med J Jan ;12(2):121-5.

OBJECTIVE:To assess the effect of low and high dose of glycyrrhizin on body weight, fasting blood sugar level (FBSL), serum insulin and glycemic indices in high fat diet induced type 2 diabetic rats.METHODS:In this experimental study with intervention period of 34 weeks, rats were grouped into four experimental groups; Group-A: normal control; Group-B: diabetic control; Group-C: glycyrrhizin-150 and Group-D: glycyrrhizin-300. Diabetes mellitus was induced in rats by giving high fat diet with injection dexamethasone. At 32 weeks, body weight, FBSL, serum insulin, Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), Homeostatic Model Assessment of beta cells (HOMA-?) and Quantitative Insulin Sensitivity Check Index (QUICKI) were estimated. Two experimental groups received glycyrrhizin 150 mg/kg and 300 mg/kg per oral per day till completion of 34 weeks in addition to the high fat diet. At 34 weeks all the parameters were re-estimated.RESULTS:It was observed that both doses of glycyrrhizin significantly reduced FBSL and insulin levels in group-C (95.00+-8.23 mg/dl, 671.60+-55.51 uIU/ml) and group-D (94.00+-6.27 mg/dl, 675.00+-44.96 uIU/ml) as compared to group-B (236.10+-13.26 mg/dl, 1052.80+-37.82 uIU/ml) [p-value<0.001] at 34 weeks. HOMA-IR decreased [group-C (157.62+-19.39) and group-D (157.03+-18.21) vs group-B (613.79+-49.91)] whereas HOMA-? [group-C (2498.23+-299.58) and group-D (2526.24+-150.65) vs group-B (1546.87+-106.81)] and QUICKI increased [group-C (0.208+-0.00) and group-D (0.208+-0.002) vs group-B (0.185+-0.001)] (P-value<0.001). Body weight decreased insignificantly in group-C (344.00+-30.21mg) (P-value>0.05) but significantly in group-D (293.20+-42.54) as compared to group-B (372.00+-24.03) [P-value<0.001]. CONCLUSION: Glycyrrhizin effectively improves glycaemic control in rat model of type 2 diabetes mellitus.

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