Arslan Abro, Faisal Siddiqui, Ahmer Ali, Afsheen Javed Khokar, Samiullah Khuhro.
The lymphocyte-to-monocyte ratio is a superior predictor of tumor stage and grade in comparison to established biomarkers of resectable colorectal cancer.
Pak J Surg Jan ;36(1):3-8.

Colorectal carcinoma is one of the most common cancer inflicting both male and female gender, more than 1.4 million cases diagnosed every year. Inspite of lot of research work and recent advances cervival in advance stages remains poor. To reduce mortality we will have to diagnose colorectal cancer at an early stag so that adjuvant chemo-radiotherapy and resection can be done. Material and methods: It is a retrospective cohert study carried in the Department of Surgery, Liaquat National Hospital and Medical College, Karachi from January 2014 till December 2016. Results: Total 139-consecutive patients of colo-rectal cancer included in this study. Aft er meeting the inclusion and exclusion criteria 96-patients were included in this study. Our result showed that low lymphocyte-to-monocyte ratio is associated with advanced tumour stage-III and IV and in comparison high lymphocyte-to-monocyte ratio was associated with tumor stage I and II. Conclusion: The lymphocyte-to-monocyte ratio is an independent and superior predictor of tumor stage and grade in comparison to the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) and can be used effectively in the management of colorectal malignancies.

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