Shafiq-ur Rehman, Farzana Sabir, Naheed Akhtar, Naila Rahman, Ishtiaq Anwar.
Diagnostic accuracy of mean platelet volume in acute appendicitis patients: a single center experience.
Pak J Surg Jan ;35(2):132-5.

Objective:To evaluate diagnostic accuracy of mean platelet volume in acute appendicitis Study design:Cross sectional study Study duration and settings: Study was conducted at the department of surgery, CMH, Muzaffarabad. Study duration was 6 months ( June 2018-November 2018). Material and Methods: A sample size of 195 patients was calculated using WHO calculator. Non probability consecutive sampling was used. Ethical approval and consent forms were taken. Patients were undergone through laboratory measurement and evaluated for diagnostic accuracy. Data was analyzed using SPSS version 24. Chi-square and ROC curve analysis was done. P-value <=0.05 was considered significant. Results: There were 195 patients included in present study. Th ere were 97(49.7%) male and 98(50.3%) female in study. Mean age of patients was 34.4 years +- 7.7SD. Acute appendicitis is significantly associated with variation in mean platelet volume value (p=0.00). Mean platelet volume had 94% sensitivity, 87% specificity, positive predictive value 86% and negative predictive value 92%.Accuracy of mean platelet volume for acute appendicitis diagnosis is 87%. Conclusion: Mean platelet volume is an effective parameter for acute appendicitis diagnosis in developing world. MPV had high diagnostic accuracy in adults as compare to other diagnostic parameters (leukocyte count and netrophil percentage) in acute appendicitis.

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