Farzana Sabir, Naheed Akhtar, Shafi Q-ur Rehman, Naila Rehman, Anam Altaf.
Comparison of antibiotic therapy and appendectomy in acute appendicitis.
Pak J Surg Jan ;35(2):120-4.

Objective: To determine the efficacy of antibiotic therapy and appendectomy in acute appendicitis in tertiary care hospital Study design: Randomized controlled trial Study settings and duration: Study was conducted at the department of surgery, CMH hospital, Muzaffarabad. Study duration was 6 months ( June 2018-November 2018) Material and methods: A sample size of 60 patients was calculated using WHO calculator. Non Probability consecutive sampling was used for patient`s selection. Ethical approval and consent forms were taken. Patients were randomly divided into two groups; group-A was given antibiotics while group-B patients were undergone appendectomy. Patients were followed aft er 8 days. Efficacy of both interventions was measured. Data was analyzed using SPSS version 24. Chi-Square test was applied. P value <= 0.05 was considered significant. Results: Total 60 patients were included in study (1:1 randomization 30 patients in each group). Th ere were 38(63.3%) male and 22(36.7%) female. Mean age of patients was 31.9+-8.8SD. Efficacy of appendectomy group was higher than antibiotic group (p=0.002). Surgical group had significant less hospital stay(p=0.00), recurrence rate(p=0.04), pain scores (p=0.00) and sick leaves(p=0.000) as compare to antibiotic group. Surgical wound infection 13.3% was most common complication in appendectomy group while appendicular mass 10% was most common complication of antibiotic. Conclusion: Appendectomy is an effective treatment option in adults patients diagnosed with acute appendicitis as compare to antibiotic therapy. Appendectomy had efficacy >50% in terms of low recurrence rate, reduction in pain scores, less hospital stay and sick leaves. Further research in needed to reveal more precise indications on acute appendicitis treatment efficacy.

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