Sabahat Tariq, Zafar Majeed, Muhammad Tariq Ghafoor.
Association of vitamin d deficiency and new onset type-2 diabetes mellitus.
Pak J Pathol Jan ;27(3):130-5.

Objective: To determine the association between vitamin D status in newly diagnosed patients with type-2 Diabetes mellitus. Study Design: Comparative cross sectional study. Place & Period of Study: Department of Pathology and Department of Internal Medicine of Sheikh Zayed Hospital and Medical College, Rahim Yar Khan; from Januarary2015 to November 2015.Method and Material: Ninety-seven newly diagnosed diabetics (subjects)and 93 non-diabetic persons (controls) were divided on the basis of their 25-hydroxyvitamin D3 (25OHD) levels in three groups, normal (>31 ng/ml), insufficient (20-31ng/ml) and deficient (<20ng/ml). 25OHD was measured by electro-chemiluminescence using Cobas e 411. Their fresh Fasting Plasma Glucose (FPG) was also estimated by hexokinase method on Beckman coulter AU 480.Results:Vitamin D levels were inversely correlated with frequency of diabetes mellitus (r=-0.20; p<0.01) with an Odd Ratio of 3.59 (95%confidence interval 1.29 to 8.70). Frequency of diabetes mellitus was significantly higher in vitamin D deficient patients as compared to patients with normal vitamin D status (p<0.05). Conclusion: The chance of diabetes mellitus increases with worsening state of vitamin D.

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