Ahsan Kazmi, Rizwan Hashim, Abdus Sattar, Farooq Ahmad Khan.
Assessment of serum leptin levels in different categories of body mass index.
Pak J Pathol Jan ;27(3):99-104.

Objective: To assess leptin concentrations in different categories of Body Mass Index (BMI) in a sample of local population of Rawalpindi, Pakistan. Study design: Observational study. Place & Duration of Study: Armed Forces Institute of Pathology and Benazir Bhutto Shaheed Hospital, Rawalpindi, 2009-2010 (8 months).Materials and Methods: Fasting serum leptin concentrations were measured in 100 healthy obese, overweight and non-obese individuals aged 20-50 years, including both sexes. ELISA test was done for serum leptin assay. For each statistical analysis SPSS version 15 was used. The mean, standard deviation, ranges p-values and r-values were calculated for statistical inference. Results: Serum leptin concentrations were strongly associated with sex and the body mass index. Serum leptin level was found comparatively higher in women, in same category of BMI, (mean-64.4 ng/ml, obese group) than in men (mean-40.4 ng/ml, obese group). The mean serum leptin concentration in non-obese women was (12.7 ng/mL) and in men (6.4 ng/mL). Body mass index was strongly positively correlated with serum leptin concentration (r=0.874, P<0.001) in obese group. Serum leptin concentrations were higher in obese individuals (mean 52.8 ? 24.6 ng/mL, P value <0.001) than in non-obese individuals (mean 12.7 ? 6.1 ng/mL). As the grade of obesity increased so does serum leptin levels. It was higher in overweight males (32.6) females (37.8), grade I males (40.4), females (64.4) obesity. Conclusion: In this sample of the local population, serum leptin concentrations correlated positively in different categories of BMI in both sexes.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com