Naseema Ahmed Jan, Raana Mahmood, Nosheen Wasi, Naila Ahmad Jan, Nargis Anjum, Huma Salahuddin.
Evaluation and Comparison of Lipid Profile in pregnancy and Preeclampsia.
Ann Abbasi Shaheed Hosp Karachi Med Dent Coll Jan ;24(4):231-7.

Objective: The objective of the study is to evaluate and compare the lipid profile in normotensive pregnancy and in pre-eclamptic pregnant women. Methods: The study was a case-control study, conducted from January 2018 to June 2018. The sample size was 90. Participants were recruited after fulfilling the selection criteria out of which, 45 were normal pregnant females and 45 were pregnant females with Preeclampsia (PE). Participants were placed in two groups namely A and B. Group A were 45 healthy pregnant females and group B were 45 preeclamptic pregnant women. The biophysical parameters included age, weight, height and BMI. Blood pressure was recorded through standard protocols. Blood was taken for lipid profile which includes Cholesterol, Triglyceride and HDL-C, measured through enzymatic colorimetric (CHOD-PAP) method, Glycerol-3-Phosphate Oxidase Phenol Amino phenanzone (GPO-PAP) method and Cholesterol Oxidase-Phenol Aminophenazone (CHOD-PAP) method respectively, however; LDL-cholesterol was calculated through Friedewald's formula. Urinary protein was measured through URS Strips through semi-automated analyser CYBOW reader 300. Data was statistically analysed through IBMSPSS software version 20 with the help of one-way analysis of variance (ANOVA) analysis, Tukey's HSD test, independent sample t-test and Pearson correlation analysis by considering p-values 0.05 as a significant. Results: The results of the study revealed significant raise in lipid profile of pregnant women with preeclampsia than in normotensive pregnant women including cholesterol, Triglyceride, HDL-C and LDL-C. Conclusion: The study concluded that dyslipidaemia or hyperlipidaemia in early pregnancy could be one of the reasons of developing preeclampsia in late pregnancy and risk of being hypertensive in advanced age.

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