Muhammad Asif Zeb, Nargis Yousif Baqai.
Evaluation of soluble transferrin receptors and ferritin level patients of beta thalassemia major.
Ann Allied Health Sci Jan ;3(1):14-6.

Aim: The purpose of this study was to evaluate sTfR and ferritin level in beta thalassemia major for diagnosis and management of iron chelating therapy. Materials and methods: This study was conducted on 400 samples from ? thalassemia major patients. ELISA technique was used for the detection of serum ferritin and sTfR according to the manufacturer`s instructions. Results: In male beta thalassemia major patients sTfR level was 89.2 +- 20.1 nmol/l while in female patients mean sTfR was 97.4 +- 23.3 nmol/l which were high on comparing with control. Serum ferritin level in male patient was 3013.35 +- 914.08 ng/ml while in female patients was 3213.43 +- 1014.08 ng/ml. Conclusion: The concentration of sTfR, and ferritin level was increased in beta thalassemia major patients which indicate increased marrow activity and increased body iron.

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