Raja Mobeen Ahmed, Muhammad Mohsin Ali, Fatima Akram, Maimoona Zamurad Khan, Raza Gulzar Ghouri, Maria Zamurad Khan.
Anxiety, Depression and Irritable Bowel Syndrome: Results from a Local Population in Pakistan.
Rawal Med J Jan ;45(2):303-6.

Objective: To find an association of IBS with anxiety and depression in a local setting. Methodology: This cross-sectional study was performed in Mayo Hospital, Lahore during July and August 2018. Patients were diagnosed by the ROME IV criteria, and the Hospital Anxiety and Depression Scale (HADS) questionnaire was used to evaluate the degree of anxiety and depression. The IBS Severity Index (IBS-SI) was used to calculate the severity of symptoms. Results: A total of 101 subjects were enrolled with mean age of 24.0 years. No relation of gender was found with subtypes, severity, anxiety and depression levels. The age groups had a significant association with the degree of anxiety and depression. Anxiety was found in 83.2% patients while 51.5% had depression. Association of IBS with anxiety and with depression was significant (p< 0.05). The IBS subtype had no relation with the levels of the psychiatric problems but had an association with the severity index. Conclusion: There was a female predominance in IBS patients. Older age groups of patients had higher levels of anxiety and depression. IBS was associated independently with anxiety and depression. IBS-Mixed was the most common subtype and had the highest severity of symptoms. The severity of disease had no relation with the levels of anxiety and depression.

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