Anum Usman, Noor Khan Lakhnana, Ayesha Sarwar, Mudassira Zahid.
Correlation of Serum IgA anti Tissue Transglutaminase Antibody levels with Histopathological grades of Celiac disease using Corazza Grading system.
Isra Med J Jan ;13(1):39-42.

Objective: To correlate serum IgA anti-tissue transglutaminase antibody levels with the histopathological grades of celiac disease using Corazza grading system Study Design: Descriptive Cross- sectional study Place and Duration: At Al Nafees Medical College and Hospital Department of Pathology from April 6, 2015 to June 10, 2016. Methodology: From all the enrolled patients, based upon inclusion and exclusion criteria, endoscopic biopsies were processed routinely for histopathological analysis. Corazza Grading system was used for grading the morphological findings. Anti-Tissue transglutaminase (tTG) IgA antibodies were measured by the ELISA (Enzyme-Linked Immunosorbent Assay) method. Both biopsy data and serological marker were correlated. Results: 77 patients were included in this study, out of which 55 were diagnosed as celiac disease patients. Gender distribution included 38.9% males and 61.1% females. According to Corraza Grading System, there were 28.6% cases in Corraza 0 and 22% cases in Corraza A whereas Corraza B1 and B2 included 35% and 14.3% cases respectively. After correlation with anti- tTG IgA Ab titers, 27.2% patients had negative serology. Total 22% patients in Corraza A were serologically positive and had IgA tTG Ab titers between 11 to 100 units/ml whereas in Corazza B1,only 18% patients had titers greater than 100 units/ml and Corazza B2 almost all patients had titers greater than 100 units/ml. Conclusion: Corazza Grading System significantly correlates with anti-tissue transglutaminase IgA Antibody titers.

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