Mahmood Yousuf, Mudabbir Hussain, Humaira Jamal Yousuf.
Topical application of Glyceryl Trinitrate 0.2% for Fissure-in-ANO.
J Surg Pak Jan ;8(1):22-4.

This study was carried out from January 2002 to August 2002 to evaluate the efficacy of glyceryl trinitrate (GTN) 0.2 % in healing of fissure in ano Sixteen consecutive patients were recruited with proven fissure in ano of more than 6 week duration. Treatment with topical GTN 0.2% was instituted. Patients were assessed at 1, 3, 6, 12 and 26 weeks. Resolution of symptoms, time taken to heal and occurrence of side effects were recorded. Success rate was 7986 at 12 weeks, reduced to 64% at 26 weeks. Two patients had recurrence of fissure; one was successfully treated with a further treatment with topical GTN while the other opted for lateral internal sphincterotomy.

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