Humayun Iqbal Khan, Fatima Tahira, Muhammad Khalid Masood, Riffat Omer, Najaf Masood, Sadia Shareef.
Antibiotic Sensitivity Pattern in Blood Culture Positive Typhoid Fever.
Pak Paed J Jan ;45(1):79-83.

Objective: The objective of this study was to find out current antibiotic sensitivity pattern of Salmonella typhi in children admitted in Pediatric Department of Services Hospital, Lahore over a period of one year. Study Design: Descriptive cross-sectional study. Place and Duration of Study: Pediatric Department of Services Hospital Lahore from 1st July 2018 till 30th June 2019. Material and Methods: The study was conducted in Pediatric Department of Services hospital Lahore over a period of 1 year after taking approval from hospital ethical review board. Blood cultures of all suspected patients of typhoid fever were obtained who presented in Pediatric department, were tested for their sensitivity pattern by disc diffusion method and were incubated at 370C for at least 7 days. Results: There were 114 positive blood cultures of typhoid fever. Out of these, 75 (66%) were from male children and 39 (34%) were from female children. All salmonella isolates were found to be resistant to ampicillin. Resistance to cephalosporin and fluoroquinolone was also high, being 89% to ceftriaxone and 94% to ciprofloxacin. However, antibiotic sensitivity to meropenem and imipenem was 100% and azithromycin was 98%. Conclusion: In this study, increased resistance to the first line drugs: ampicillin, chloramphenicol and trimethoprim-sulfamethoxazole along with second line drugs fluoroquinolones and cephalosporins was seen when these were used for the treatment of enteric fever. Unfortunately, we have been left with only few drugs like meropenem and azithromycin that have shown more than 98% sensitivity to the salmonella as can be inferred from this cohort.

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