Nighat Kafil, Kausar Aamir, Shah Murad, Jamal Ara, Saadia Anjum.
A placebo controlled clinical trial on Nimesulide in Osteoarthritis.
J Surg Pak Jan ;8(2):5-8.

Osteoarthritis is a chronic, progressive articular disorder characterized by pain. The prevalence of this most common joint disease rises with increasing age and occurs in approximately 85% of people between 75 to 79 year of age. Simple analgesics are useful in patients with mild disease, although nonsteroidal anti inflammatory drugs (NSAID) are the main stay of therapy. Nimesulide is an NSAID that has demonstrated clinically significant anti inflammatory, analgesic and antipyretic activity in a variety of painful inflammatory conditions, including osteoarthritis. We compared nimesulide with placebo in groups of 30 patients each and were able to see a highly significant improvement in the parameters of pain at rest, pain on movement and tenderness while placebo group showed non significant improvement in all the symptoms in a study conducted for 90 days. Nimesulide was well tolerated with mild side-effects.

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