Nadia Ahmad, Ammara Ghafoor, Muhammad Shahid Jamil.
Acetaminophen induced hepatotoxicity and effects of pomegranate peel extract on livers of adult male albino rat.
J Sharif Med Dent Coll Jan ;2(02):61-5.

Objective: To observe the effects of pomegranate peel extract on acetaminophen-induced hepatotoxicity. Methodology: A randomized control study was conducted at the University of Health Sciences, Lahore, Pakistan. Twenty four rats weighing 175+25gm each were included in this study. Animals were divided into three groups: A, B & C by random balloting method. Group A served as control and was given 5ml/kg normal saline intraperitoneally. Group B & C were given on day 1 intraperitoneally 750 mg/kg acetaminophen dissolved in 5 ml/kg normal saline. Group A & B received 5 ml/kg normal saline orally from day 2 till day 14 of experiment whereas group C received pomegranate peel extract (PPE) 50mg/kg dissolved in 5ml/kg distilled water orally. After 14 days of experimental period animals were sacrificed and their livers were removed and processed for histological examination. Results: Mean body weight at end of experiment in group B showed marked decrease as compared to group C. Histological examination of group B showed necrosis with vacuolar degeneration and a number of apoptotic bodies. Results of group C showed preservation of normal histological architecture. Conclusion: Pomegranate peel extract due to its antioxidant property remediated the effect of acetaminophen induced hepatotoxicity. Keywords: Hepatotoxicity. Apoptotic bodies. Acetaminophen. Pomegranate peel.

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