Amjad Mustafa, Shabir Hussain, Ghazala Shaheen.
Comparison of Efficacy of Terbinafine and Fluconazole in patients of Tinea Corporis.
Annals Punjab Med Coll Jan ;15(1):21-4.

Background: Tinea corporis is a worldwide superficial fungal infection that mimics many other annular lesions. As the Tinea Corporis have a significant impact on patient`s life physically and psychologically. So, physicians must have knowledge about this condition and its treatment options. Objective: To compare the efficacy of terbinafine versus fluconazole in patients of tinea corporis. Study Design: It was a randomized controlled trial. Settings: Research was conducted at Department of Pharmacology Duration: for a period of 6 months from 10 Feb to 10 Aug 2020 at Khalifa Gulnawaz Teaching Hospital, Bannu, Khyber Pakhtunkhwa & DHQ Teaching Hospital, Bannu, Khyber Pakhtunkhwa Pakistan. Methodology: From both the genders 102 patients aged between 20-45 years who presented with tinea corporis were included in the study. Two treatment groups were made by random allocation of patients. Patients in Group-A were treated with oral terbinafine while those in Group-B were given fluconazole. Frequency of efficacy being outcome variable was labeled upon complete resolution of the tinea corporis in 4 weeks (counted from start of treatment) and was compared between the groups. An informed written informed consent was taken from all the patients. Results: The patients had a mean age of 31.66�6.99 years while the mean duration of disease was 5.41�2.16 months. There were 55 (53.9%) male and 47 (46.1%) female patients with a male to female ratio of 1.2:1. The frequency of efficacy was significantly higher in patients treated with terbinafine as compared to fluconazole (90.2% vs. 64.7%; p-value=0.002). This difference was same in all subgroups as well. Conclusion: Oral terbinafine was found more efficacious than conventional treatment with oral fluconazole in patients with tinea corporis regardless of patient`s age, gender and duration of disease which advocates preferred use of terbinafine in the treatment of such patients in future practice.

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