Qurat-ul Ain, Aqsa Aslam.
Pattern of sFit-1 antiangiogenic serum marker in pregnancy-induced hypertension in Sharif Medical City Hospital, Lahore.
J Sharif Med Dent Coll Jan ;3(02):72-5.

Objective: To investigate the maternal serum level of antiangiogenic factor sFit-1 in pregnancy-induced hypertension (PIH) at different gestational ages in Sharif Medical City Hospital (SMCH), Lahore. Methodology: The present descriptive case-control study evaluated maternal serum levels of antiangiogenic marker sFlt-1 in 90 women with gestational age 18-40 weeks referred to SMCH, Lahore. It included 69 pregnant women with hypertension and 21 normotensive pregnant control subjects. The hypertensive patients were taking methyldopa. Out of 69 hypertensive pregnant subjects, 24 had gestational hypertension (GH), 41 had preeclampsia (PE) and 4 had eclampsia (EC). The indicators of blood pressure, urinary albumin and convulsions were the principals in categorizing the hypertensive pregnancy in GH, PE and EC. The age, parity, BMI, urinary albumin and hemoglobin were also noted and measured. The antiangiogenic serum biomarker was analyzed and assessed with enzyme-linked immunosorbent assay (ELISA). Results: The average serum concentration of sFit-1 was 33% lower in hypertensive pregnant women as compared to normotensive control subjects. The difference was statistically significant (p=0.05). In GH, sFit-1 concentration was 28% lower than controls. In PE, sFit-1 level was 37% lower than the normotensive subjects and in EC patients, sFit-1 level was 25% lower than the normotensive subjects. It had been observed that PE subjects exhibited a maximum decrease in sFit-1 among all hypertensive subjects. There is also a significant difference in sFlt-1 levels at different gestational ages. Conclusion: The serum sFlt-1 levels in pregnancy-induced hypertension women are higher than normotensive women. In our study, the serum levels of antiangiogenic factor sFit-1 in pregnancy-induced hypertension are lower than normotensive pregnant women. This is attributed to the use of methyldopa in these patients. Keywords: Antiangiogenic markersFll-1. Pregnancy-induced hypertension. Preeclampsia. Eclampsia.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com