Almas Raza, Aqsa Aslam, Sadaf Munir, Maria Aslam, Saima Inam, Madiha Ehsan-ul Haq.
Frequency and Antimicrobial Susceptibility Pattern of Multidrug Resistant Acinetobacter Species in Sharif Medical City Hospital, Lahore.
J Sharif Med Dent Coll Jan ;4(02):79-84.

Objective: To determine the frequency and antimicrobial susceptibility pattern of multidrug resistant Acinetobacter species in different clinical specimens of Sharif Medical City Hospital, Lahore. Methodology: It was a cross-sectional study conducted in the Department of Pathology, Sharif Medical City Hospital, Lahore over a period of one and a half year (from May 2017 to October 2018). The study was approved by the ethical committee of the institution. A total of 2490 clinical specimens were received in the Pathology laboratory for culture and sensitivity from different departments of the hospital and were processed by conventional bacteriological methods for isolation and identification. The antimicrobial susceptibility testing was done by Kirby-Bauer disc diffusion method as recommended by Clinical and Laboratory Standard Institute (CLSI). The Statistical Package for Social Sciences (SPSS) version 25 was used for data entry and analysis. Results: Out of the 2490 culture specimens, 51(2%) positive cultures for Acinetobacter species were obtained. Most of the patients with the positive culture were between 19 to 50 years of age. The various clinical specimens from which Acinetobacter species were isolated were 34 pus/ wound swabs followed by 8 blood, 3 urine, 3 tips (2 center venous catheters, 1 endotracheal tube), 2 sputum and 1 body fluid. The majority of the specimens were received from various outpatient departments, ICU and nursery. Thirty one percent strains were sensitive and 6% were intermediate to cefoperazone-sulbactam. Most of the isolates were resistant to other antimicrobials. Five (9.8%) strains of Acinetobacter species were resistant to all of the antimicrobials. Conclusion: The prevalence of Acinetobacter species is low in different clinical specimens for culture and sensitivity in Sharif Medical City Hospital, Lahore. Thirty one percent strains were sensitive and 6% were intermediate to cefoperazone-sulbactam. All the strains of Acinetobacter species were multidrug resistant. Five (9.8%) strains of Acinetobacter species were resistant to all of the antimicrobials. However, the emergence of infections by multidrug resistant Acinetobacter species is an alarming sign in the hospital setting. Keywords::Nosocomial pathogen. Acinetobacter species. Multidrug resistance.

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