Madiha Ehsan-ul Haq, Mohammad Faisal, Sabiha Riaz, Rizwan Ullah, Almas Raza.
Expression of Immunoglobulin G in Breast Cancer on Immunohistochemistry.
J Sharif Med Dent Coll Jan ;4(02):71-4.

Objective: To determine the frequency of expression of Immunoglobulin Gimmunohistochemical stain in breast cancer. Methodology: It was a descriptive cross-sectional survey. The study was conducted in the Department of Histopathology, Fatima Memorial Hospital, Lahore from 10th July 2015 to 9th January 2016. The study was approved by the ethical committee of the hospital. A total of 70 cases of breast cancer presented and diagnosed at Fatima Memorial Hospital were included in this study. The demographic details of the patients such as name and age were noted. The received specimens were fixed in 10% buffered formalin, grossed and slides were prepared from tissue blocks which were stained with hematoxylin and eosin. The morphology was reviewed and immunohistochemical staining for IgG was performed. Immunohistochemical IgG staining was assessed independently and it was recorded in terms of IgG positive and IgG negative cases. Results were verified by consultant histopathologist. The data was analyzed using SPSS version 24. Results: In our study, out of 70 patients of breast cancer, 57.1% (n=40) were between 25-50 years of age while 42.9% (n=30) were between 51 85 years of age. Sixty nine (98.6%) patients were females and 1(1.43%) patient was male. Invasive mammary carcinoma of no special type was the commonest tumor type and seen in 66(94.3%) cases. Grade 2 tumors were recorded as 65.71% (n=46) and grade 3 tumors were recorded as 34.29% (n=24). Out of 70 cases, 92.75% (n=64) were not associated with ductal carcinoma in situ whereas 7.25% (n=5) had an associated ductal carcinoma in situ. Receptor studies showed that 52.27% (n=23) cancers had positive estrogen receptor expression, 52.27% (n=23) had positive progesterone receptor expression and 56.81% (n=25) had Her2/neu positive expression. The frequency of expression of immunoglobulin G immunohistochemical stain was recorded as positive in 55.71%(n=39) breast cancers. Conclusion: The frequency of expression of Immunoglobulin G immunohistochemical stain is less (55.7%) in breast cancer in our population but has significant value (p-value <0.05) with regards to higher grade and histological subtype of breast cancers. Keywords: Breast cancer. Immunoglobulin G. Immunohistochemical stain.

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