Nazish Jamil, Qurat-ul Ain, Ejaz Ahmad, Sana Javaid, Umer Jamil, Shafeen Zulfiqar.
Serum Vitamin D, Superoxide Dismutase and Catalase Levels in Females with Uterine Fibroid.
J Sharif Med Dent Coll Jan ;5(2):75-9.

Objective: To determine the serum vitamin D, superoxide dismutase and catalase levels in females with uterine fibroids. Methodology: This study was performed in the Obstetrics & Gynaecology Department of Sharif Medical City Hospital, Lahore after taking approval from the ethical committee of the institution. It was a case-control study that included 25 females of reproductive age (25-45 years) having uterine fibroid diagnosed on ultrasonography & 25 females were enrolled as age and gender matched controls. Informed written consent was obtained from all patients before taking the blood sample. Serum vitamin D, SOD and CAT levels were measured by ELISA kit. Results: This study analyzed serum vitamin D and antioxidant enzymes SOD and CAT levels in uterine fibroid women which were compared with healthy women (non-fibroid females) of the same age group. The mean levels of vitamin D and antioxidant enzymes SOD & CAT in patients with uterine fibroid were 11.29 1.08 pmol/L, 0.13 0.0019 U/ml and 3.30 0.0264 U/L respectively. In the control group the levels of vitamin D, SOD & CAT were 17.88 2.16 pmol/L, 0.49 0.0034 U/ml and 5.26 0.376 U/L respectively. The levels of vitamin D and antioxidant enzymes SOD and CAT were found significantly decreased in females with uterine fibroid as compared to the controls. Conclusion: The levels of vitamin D and antioxidant enzymes SOD and CAT are decreased in uterine fibroid females in comparison to the healthy females. It indicates a positive relationship between reduced levels of vitamin D, SOD and CAT to the risk of development of uterine fibroid. So, vitamin D and antioxidants supplementation might reduce the risk factor of uterine fibroid and can be helpful in the non-surgical treatment of uterine fibroid. Keywords: Uterine fibroid. Serum vitamin D levels. Superoxide dismutase (SOD). Catalase (CAT). ELISA.

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