Shoaib Tounus, Abru Fatima, Muhammad Nadeem, Uzair Bin Akhtar, Mustafa Ayub Khawaja, Komal Akram.
Effects of Corticosteroid versus Placebo in Controlling Post-Procedural Sequelae after Impacted Third Molar Surgery: a Randomized-Controlled Trial.
J Sharif Med Dent Coll Jan ;6(1):15-20.

Objective: To compare the outcome of dexamethasone versus methylprednisolone in controlling post-procedural pain and better mouth opening after impacted 3" molar surgery. Methodology: This single-blinded randomized controlled trial was done at the Department of Oral & Maxillofacial Surgery, Sharif Medical & Dental College, Lahore over a period of 6 months. Forty five patients requiring 34 molar removal were enrolled in the study through a probability consecutive sampling technique. Patients were divided randomly into three groups. Group A was given dexamethasone, group B was given methylprednisolone and in group C placebo was given. Surgical removal of 3ta molar was carried out, pain and mouth opening was assessed preoperatively and postoperatively on day 1 and 7 after surgery. Results: The difference in pain score was insignificant (p>0.05) at baseline but significant after 1* & 7 postoperative day among all groups. Pain was significantly low in group A & B than group C (p <0.05). However, group A & B had an insignificant difference in pain. In all three groups, mouth opening was decreased significantly at day 1 after surgery but later on increased significantly on day 7". The difference in mouth opening was insignificant (p>0.05) at baseline but significant after 18 and 7" postoperative day (p<0.05). Mouth opening was more in group A & B as compared to group C. Conclusion: Corticosteroids can reduce pain and significantly improve the mouth opening i fgiven before 3d molar extraction. Keywords: Dexamethasone. Methylprednisolone. Post-procedural pain. Mouth opening. Impacted third molar surgery.

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