Maha Shahbaz, Shamshad Ali, Saqib Siddiq, Alina Mustafa, Khawaja Mohsin Ihsan, Fiza Azhar.
Efficacy of nepafenac in maintaining mydriasis during phacoemulsification surgery.
Rawal Med J Jan ;45(4):810-2.

Objective: To evaluate the efficacy of nepafenac 0.1% in maintaining mydriasis during phacoemulsification surgery. Methodology: This randomised control RCT is of six-month duration was performed on 120 patients who were randomized in 2 groups. The study group was given 3 drops of nepafenac 1 day prior to surgery and 4 drops on the day of surgery in addition to the preoperative dilating drops (tropicamide 1% and epinephrine 0.5%) one hour before surgery, repeated after 30 minutes. Control group received only pre-operative dilating drops. Calipers were used to measure pupil size immediately before and at end of surgery. The difference in size was noted and the decrease in pupil size was calculated using SPSS 21.0. p<0.05 was considered significant. Results: Out of 120 patients, 42(35%) were male and 78(65%) female. The mean age was 52.13+-7.34 years in control group and 52.93+-7.09 years in nepafenac group. At baseline in nepafenac group, pupil size was 7.74+-0.92 mm and 6.3+-0.99 mm at the end of surgery. Mean decrease was 0.9+-0.89 mm. In the control group, pupil size was 7.6+-0.61mm before surgery and 5.84+-0.56 mm at end of surgery. Mean decrease in pupil size was 1.76+-0.81mm. The difference in the two groups was significant (p<0.001). Conclusion: The use of nepafenac 0.1% during phacoemulsification surgery can be beneficial in maintaining mydriasis.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com