Sadia Ijaz, Israrul Haque, Muhammad Muzammil Bajwa, Junaid Mushtaq, Ghias Un Nabi Tayyab, Mujtaba Hassan Siddiqui.
Levels of Immature Platelet Fraction in patients of Acute Coronary Syndrome.
J Sharif Med Dent Coll Jan ;7(01):37-42.

Objective: To measure the level of immature platelet fraction in patients with the acute coronary syndrome. Methodology: It was a cross-sectional comparative study conducted at the Department of Pathology, Postgraduate Medical Institute, Lahore from November 2017 to November 2018. One hundred and seventy respondents were included and divided into two groups, a case group, and a control group. In the case group, 85 patients of acute coronary syndrome and in the control group, 85 age-matched normal healthy individuals were included using a non-probability convenient sampling technique. The immature platelet fraction (IPF) was measured in both groups using Sysmex haematology analyser (XN-1000). An independent sample t-test was applied to compare the mean of normally distributed data in both groups. Results: The ages of the patients in case group ranged between 18-86 years and in control group 17-80 years. No statistical significant difference was found when the age of the patients and the controls were compared (p-value >0.05). In the case group, there were 45(26.47%) males and 40(23.53%) females whereas in the control group there were 47(27.65%) male and 38(22.35%) female cases. The mean immature platelet fraction in the case group and control group was 8.716+/-6.2834% and 3.83+/-1.63%, respectively. A significant difference was found in the comparison of mean IPF in the case & control groups (p-value <0.001). Conclusion: The levels of immature platelet fraction were raised among patients with the acute coronary syndrome. So, increased levels of IPF can lead to other thrombotic events or unfavorable prognosis in patients with acute coronary syndrome (ACS). Keywords: Immature platelet fraction. Mean platelet volume. Acute coronary syndrome. Cardiovascular disease.

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