Bushra Tasneem, Aisha Tasneem, Fauzia Lateef, Saba Jamal, Rahil M Rehman, Abdullah Muttaqi.
Histopathological findings of gall bladder specimen after cholecystectomy.
Pak J Surg Jan ;37(2):94-9.

Objective: Cholecystitis is a generally widespread problem in adult population. Multiple findings have been found in gross and microscopic examination of gallbladder. Existence of stones is one of the known causative factors that lead to histopathological changes in gallbladder. It is also responsible for the development of gallbladder carcinoma. The purpose of this study was to find out the histopathology of gall bladder specimens following surgical intervention. Study design: Observational study Place and duration of study: This study was conducted at Surgery Department of Abbasi Shaheed Hospital and Pathology Department of Ziauddin Hospital, from January 2017 to February 2020. Material and Methods: This observational study included 2,320 patients with acute or chronic cholecystitis secondary to gallstones that were admitted through the outpatient Department. Non-probability convenient sampling technique was used. Written en and informed consent was taken from all the participants. Data was analyzed using SPSS version 20. Descriptive analysis was performed. Results: A total of 2,320 gallbladder specimens that presented for histo-pathological examination during the study period were included into the study, with male to female ratio of 1:3. Th e highest prevalence was found in the age group of 31-50 years. The results of histopathological examination of these gallbladder specimens showed that chronic cholecystitis was found in 1353 (58.3%), acute cholecystitis in 469 (20.2%), Gangrenous cholelithiasis 33 (1.4%) and cholestrolosis in 333 (14.3%) patients. Dysplasia was found in 8 (0.34%) patients, and gall bladder carcinoma was detected in 16 (0.69%) patients. There were 2181(94%)cases of calcular-cholecystitis. On morphological analysis, the commonest gall stones were made up of cholesterol and the most common lesion was chronic cholecystitis by histopathology. Conclusion: This study concludes that the chronic calcular-cholecystitis was dominant in our population. It is assumed that routine histopathological examination following cholecystectomies essential for all gallbladder specimens even in the non-existence of macroscopic signs of carcinoma, which was the case in our patients.

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