Azim M, Khan A H, Khilji Z L, Pal J A, Khurshid M.
Chromosomal abnormalities as a cause of recurrent abortions: a Hospital Experience.
J Pak Med Assoc Jan ;53(3):117-9.

Objective: To analyze the chromosomal abnormalities in couples with history of recurrent abortions. Design: Retrospective study. Setting: Cytogenetic section, Department of Pathology at the Aga Khan University Hospital, Karachi, Pakistan. Patients: Three hundred couples with history of recurrent abortions. Main outcome measure: Structural chromosomal abnormalities in carrier couples. Results: G-banded chromosomes were analyzed from both partners of 300 couples who had had two or more spontaneous abortions. Sixteen (5.3%) couples showed a chromosomal aberration in one of the partners. Seven translocations, 5 inversions, 2 deletions and 2 sex chromosomal abnormalities were identified. There was an increase in structural aberations, which was not significantly different from that reported worldwide. Conclusion: Chromosomal analysis is advocated as a primary tool in the evaluation of couples with repetitive fetal wastage (JPMA 53:117;2003).

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com