Shabana Noreen, Ghazala Shaheen, Muhammad Akram, Abid Rashid, Syed Muhammad Ali Shah.
Antiurease and anti-oxidant activity of Vaccinium macrocarpon fruit..
Pak J Pharm Sci Jan ;29(4-S):1383-5.

The objective of present study was to evaluate the antiurease and anti-oxidant activity of Vaccinium macrocarpon fruit. The parent extract was ethanolic extract while its sub fractions were prepared in n-hexane, chloroform and n-butanol. The method based on scavenging activity and reduction capability of 1, 1-diphenyl-2-picrylhydrazyl radical (DPPH). N-butanol fraction was the most effective antioxidant with 87.0+/-1.15 activity but the activity was less than ascorbic acid i.e. 93.74+/-0.12. Highly significant urease inhibition was shown by crude ethanolic extract (71.00+/-0.2a) with IC50 (392.66+/-2.1) followed by aqueous fraction (68.00+/-0.5e) with IC50 (159.83+/-2.8). The results of crude ethanolic extract and aqueous extracts were highly significant (p<0.05) than standard Thiourea. Present study showed that Vaccinium macrocarpon exhibits potent antiurease and antioxidant activities.

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