Muhammad Tariq, Amir Bukhsh Kalhoro, Mian Saeed Sarwar, Hamayun Khan, Shakoor Ahmad, Sayed Mubashir Hassan, Arshad Zahoor.
effects of medetomidine on serum glucose in cattle calves..
Pak J Pharm Sci Jan ;29(3):941-4.

An experimental study was carried out to compare physiological effects (serum glucose level) of medetomidine in Red Sindhi cattle calves at three different doses i.e. 8, 10 and 12microg/kg body weight intravenously. Medetomidine produced a dose dependent significant (P<0.01) increase in serum glucose level with a maximum increase observed at 30 minutes with 8microg/kg, 10mug/kg and 12mug/kg body weight respectively. Start of sedation, degree of sedation and total duration of sedation were all dose dependent and the values obtained were significantly (P<0.01) different from each other. It was observed that the sedation was rapid, deep and longer with the higher doses of medetomidine i.e. 12mug/kg. The results of the present study shows that medetomidine is a very effective and safest drug use as sedative for calves which in lower doses (8mug/kg) can be used as a pre-anesthetic and for restraining of the animal, while higher calculated doses (10mug/kg, 12mug/kg) can be used to execute the minor surgical procedures.

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