Sabahat Naeem, Shamim Akhtar, Nadia Asghar, Sikander Khan Sherwani, Nousheen Mushtaq, Arfa Kamil, Shaista Zafar, Mohammad Arif, Zafar Saeed Saify.
Antimicrobial and antioxidant screening of N cent-substituted sulphonyl and benzoyl derivatives of 4-Pyridine carboxylic acid hydrazide..
Pak J Pharm Sci Jan ;28(6):2129-34.

In this research program, the antibacterial, antifungal and antioxidant activities of six N'-substituted sulfonyl and benzoyl derivatives of lead molecule PCH were reported. Out of these compounds, sulphonyl derivatives 2,3 and benzoyl derivative 5 showed moderate to good activity against different strains of gram-positive and gram-negative bacteria including B. cereus, B. subtilis, B. thruingiensis and S. pyogenes, S. fecalis and E. coli ATCC 8739. Moreover, upon antifungal screening, the compound, N cent-[(2,4,6-trimethylbenzene) sulfonyl]pyridine-4-carbohydrazide possessed good antifungal activity against Candida species, a causative agent of systemic fungal infections. Antioxidant study demonstrated more than 50% inhibition in DPPH assay for sulphonyl derivative 2 indicating its potential as antioxidant while the other derivatives expressed low level of radical scavenging property.

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