Durre Shahwar, Sami Ullah, Mohammad Akmal Khan, Naeem Ahmad, Afifa Saeed, Saif Ullah.
Anticancer activity of Cinnamon tamala leaf constituents towards human ovarian cancer cells..
Pak J Pharm Sci Jan ;28(3):969-72.

Bioassay guided fractionation of Cinnamon tamala leaf extracts yielded bornyl acetate (1), caryophylene oxide (2), p-coumaric acid (3) and vanillic acid (4) using A-2780 human ovarian cancer cell lines. The structures of the isolated compounds were confirmed through spectroscopic techniques (EIMS, (1)H and (13)C NMR). Compound 1 exhibited highest cytotoxicity with 90.16 +/- 1.06% inhibition (IC50=5.30 x 10(-4) mg/ml) followed by compound 2 (84.40+/-1.53% inhibition; IC50=8.94 x 10(-3)mg/ml), while compounds 3 and 4 were inactive in the bioassay.

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