Hakim Ali Abro, Asma Hameed, Mehwish Ejaz, Hamid Khalil.
Comparison of Sensitivity and Specificity of Aspartate Aminotransferase to Platelet Index (APRI) and FIB-4 with Transient Elastography: Fibro Scan in Chronic Hepatitis C Virus Infected patients.
Pak J Med Health Sci Jan ;14(2):750-3.

Aim: To compared readily available non-invasive fibrosis indexes with fibro scan for the fibrosis staging and predicting its progression in Pakistani population. Study Design: Retrospective cross-sectional study Place and Duration of Study: Department of Medicine, Chandka Medical College Hospital, Larkana from 1st July 2019 to 31st December 2019. Methodology: One thousand four hundred and sixty four hepatitis C virus (HCV) infected patients were got complete blood count, liver function tests, enzyme-linked immunosorbent assay, polymerase chain reaction and fibro scan done to perfectly diagnose ongoing hepatitis C infection. In order to differentiate HCV fibrosis progression, we compared the effectiveness of readily available aspartate aminotransferase (AST) to Platelet Index (APRI) and FIB-4 with fibro scan. Results: Readily available serum indexes AST to Platelet Index and FIB-4 were able to stage liver fibrosis in advanced stages of fibrosis (F4 especially) with correlation coefficient indexes 0.462, and 0.131 with considerable specificities and sensitivities. For APRI >1.5, it did predicted F4 stage with sensitivity of 87.6% and specificity of 74.8%. For Fib-4> 3.25, it did predicted F4 stage with sensitivity of 72.3% and specificity of 53.2%. Conclusion: Readily available and cheap serum indexes, AST to Platelet Index (APRI) and FIB-4 accurately predicted distinguished between cirrhotic and non-cirrhotic stages in HCV infected patients in comparison to the costly and rarely available Fibro scan score.

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