Bilal Rafique Malik, Hamid Khalil, Mehwish Ejaz.
Efficacy of Terlipressin and Albumin for treatment of Hepatorenal Syndrome of a tertiary care hospitals.
Pak J Med Health Sci Jan ;14(2):747-9.

Background: Hepatorenal syndrome (HRS) is a fatal complication of advanced cirrhosis with ascites and liver failure, with nearly 50% of patients dying within 2 weeks after the onset. HRS reportedly occurs in 7%-15% of patients with advanced cirrhosis and ascites; the estimated annual incidence of HRS in the United States is approximately 9,000-14,000 patients Aim: To compare the efficacy of Terlipression and albumin for treatment of hepatorenal syndrome Setting: Department of Medicine, East Medical Ward , Mayo Hospital, Lahore. Duration: .From January to December 2019. Methods:: Randomized control trial. Patients were randomly allocated in 2 groups by using computer generated random numbers table,30, 30 patients included in Group A and Group B. Terlipression plus Albumin was given in group A and dopamine was given in group B. Independent sample t test was applied for continuous variables and chi square test was used for categorical parameters. P value < 0.05 was considered as statistically significant Results: The mean age of Group A was 38.43 +- 10.94years and the mean age of Group B was 40.56 +- 12.44 years. There were 13(43.3%) and 12(40%) females in group A while there were 17(56.7%) females and 18(60%) females in group B. Among groups, Efficacy was present in 21(70%) in group A patients out of which 30 cases. But among controls, Efficacy was present in 12(40%) in group B patients out of which 30 cases. There was statistically significant difference was observed between both groups (p<0.001) Conclusions: Terlipressin with albumin an effective therapeutic intervention for hepatorenal syndrome as compare to dopamine.

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