Jahanzab Salim, Ambreen Shabbir, Shahid Hamid, Fatima Mohsin, Muhammad Umer Talha, Muhammad Awais Amjad.
Histological Evidence of Red Velvet Mite Extract as Hepato-Renal Protective Agent.
Pak J Med Health Sci Jan ;14(2):687-91.

Background: Dugs formed from animals are in common use today for their effective results in treatment. Aim: The goal was to appraise hepato-renal protective effect Dinothrombium tacnitorium methanolic extract in Albino rats on their histological basis. Study design: It was a randomised control study. Methodology: Aqueous methanolic extract (70% v/v) of Dinothrombium tacnitorium (Dt.Cr) was prepared followed by succeeding evaporation using rotary evaporator. Liver and renal toxicity was done by introduction of CCl4 (2 ml/kg, p.o) in paraffin oil on 7th day of experiment. By the end of project, liver and kidneys were taken out under anesthesia. They were sectioned into 5 um by microtome. They were stained with Eosin-Hematoxylin dye. They were observed for histo-pathological changes. Administration of methanolic extract of Dinothrombium tacnitorium (300mg/kg body weight/day) orally protected against the CCl4 induced elevation of liver enzymes as well as renal serum markers. All hepatic enzymes and renal markers were elevated in the CCl4 alone treated animals. Administration of methanolic extract to CCl4 challenge protected against the hepato-renal toxic agent. Conclusion: Histological findings suggested that the red velvet mite methanolic extract reduces the histopathological changes in both liver and kidneys due to CCl4-induced toxicity in albino rats thus it can work as hepato-renal protective agent.

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