Madiha Arshad, Shahida Niazi, Qurat-ul Ain.
Histopathological study of Prostatic Lesions in a Tertiary Care Hospital, Lahore.
J Sharif Med Dent Coll Jan ;7(02):54-60.

Objective: To determine the spectrum of pathological lesions seen in prostatic biopsies & to grade prostatic cancers according to the modified Gleason score & grade. Methodology: It was a retrospective study conducted at the Department of Pathology, Mayo Hospital/King Edward Medical University, Lahore commencing from January 2018 to December 2020. Previous histopathology reports, blocks, & recut slides were studied for the type of biopsy specimen, age of the patient, histopathological diagnosis, and morphological patterns (Gleason score and grade) in cases of prostatic carcinoma. Results: A total of 629 prostate specimens were received during the study period. These constituted 500(79.49%) transurethral resection of prostate (TURP) specimens, 87(13.84%) core needle biopsies, and 42(6.67%) radical prostatectomy specimens. The specimens constituted 549(87.28%) benign lesions and 80(12.71%) malignant cases. Benign lesions included benign prostate hyperplasia constituting 461(73.3%) cases & hyperplasia associated with prostatitis constituting 88(14%) cases. Malignant cases included 76(12.1%) cases of prostatic adenocarcinoma and 4 cases of metastatic deposits. Two hundred and twenty eight (41.53%) cases of benign prostatic hyperplasia and 37(46.25%) cases of prostatic carcinoma were observed in 61-70 years age group. Collectively, a total of 543(86.73%) cases were seen in the age range of 51-80 years. The maximum number of prostatic cancers (45 cases/59.20%) had the highest Gleason scores of 9 & 10(grade group 5) & only 2 cases had the lowest score of 6(grade group 1). Conclusion: Benign prostatic hyperplasia & prostatic carcinoma are the two most common pathological lesions affecting the prostate. Keywords: Benign prostatic hyperplasia. Prostatitis. Prostate adenocarcinoma.

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